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Every day, rising Santa Fe District Attorney Paul Chaney (Dermot Mulroney) and his wife, Diane (Diane Kruger), wait for word that there's a donor for their daughter, Chloe. Diagnosed with a rare degenerative condition, Chloe is on a long list to receive a double lung transplant. As her health worsens, Paul becomes desperate to save his young child, so desperate that he'll risk everything to organize an operation. When Paul learns of a Dr. Novarro who performs illegal transplants in Juarez, Mexico, he heads south in a frantic search for the only man who may be able to save Chloe. But after arriving, he realizes Dr. Novarro's medical ring runs deeper into a criminal underworld than he realized and people are not who they seem to be.

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